Mesothelioma Symptoms, Diagnosis and Treatment

There's a theme gliomas and aggressive cancer that attacks the Mesothelium, which is a thin membrane made of epithelial cells that lines all of the body's organs as well as body spaces like the thoracic cavity and the abdominal cavity. Mesothelioma most often develops in the lining of the lungs and pleural cavity and is well known for its association with the carcinogen asparagus. In fact, the late Hollywood actor Steve Mcqueen's, known for having developed Mesothelioma after years of asbestos exposure while in the military. That being said, the vast majority of Mesothelioma cases stem from a specified exposure assessed. This is a mineral that was widely used as construction material and everything from paint to insulation to roofing tiles because as strong fibers that were resistant to fire and served as good insulation, especially as fibers, are jagged in shape and extremely tiny, about 500 times finer than a human hair.

Mesothelioma Symptoms, Diagnosis and Treatment

If those tiniest bestest fibers get inhaled over time, they make their way into the interstitial space of the lungs and then slowly make their way over to the epithelial cells of the visceral or parietal Pleura. Both of which are layers of the mesothelium microscopic jaggedness best is fibers are so small that they can get tangled up with the sales chromosomes. At that point, they can damage the DNA causing a variety of mutations which ultimately allow those epithelial cells to divide uncontrollably turning into a tumor over time. Small cancerous growths called mesothelial plaques start to cover the visceral pleura over the lungs as well as the parietal pleura under the chest wall. Interestingly, these growth start to express a lot of cal retina in a calcium binding protein involved in regulating calcium levels within the cell and this is something that helps distinguish mesotheliomas from other types of tumors.

In addition to affecting the lungs in pleural lining as best as fibers can also end up in the stomach if saliva containing the material or mucus from the airways is swallowed. Research is also being done to find out whether it's best is fibers are capable of traveling through the lymphatic system because this best is fibers effect epithelial cells. They can cause Mesothelioma in nearly any of the body's internal organs, but it's most commonly found in the lungs, in abdominal organs like the liver, the spleen and the bowel or in very rare cases, the pericardium lining of the heart and the testes.

Symptoms of Mesothelioma affecting the lungs or parietal pleura include chest pain, shortness of breath, pleural effusions, and if the tumor invades into a blood vessel, it can result in bloody sputum. Occasionally a Mesothelioma can also destroy the lung tissue between the bronchial tree in the pleural space leading to a pneumothorax which is air in the pleural space. Diagnosing and Mesothelioma typically starts with a chest x ray or a CT scan with key findings being pleural thickening as well as pleural effusion or pneumothorax. Ultimately though the diagnosis is made with a biopsy of the tumor in suspected cases of Mesothelioma, the tissue sample can be immunostain with an antibody that reacts with the Protein Cal Retina and this gives the cytoplasm and nuclei the cancerous cells a distinctive fried egg shape.

Unfortunately, the prognosis for Mesothelioma is poor unless it's caught early. This is because the cancer is extremely resilient and is typically spread to multiple organs by the time it's detected. Treatment depends heavily on the stage of the disease and usually combine surgery, chemotherapy and radiation. All right. As a quick recap, Mesotheliomas and his bestest related cancer that usually involves the lining of the lungs and pleural lining under the chest wall. Tiniest bestest fibers get inhaled, make their way into epithelial cells and cause DNA damage, which ultimately leads to the formation of mesothelial plaques and pleural thickening.